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Botox, Xeomin and Corporate Espionage

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On Friday, March 9, US District Judge Andrew Guilford entered an injunction against Merz Pharmaceuticals in his Santa Ana, California court chambers. This prohibits Merz from selling filler products or Xeomin or soliciting the purchase of filler products or Xeomin in the facial aesthetic market for 10 months from the date of the order, except in limited circumstances. Merz has to also do a number of other things and report on these to the court in 6 month intervals for the next year in a half. This took place about a week before Merz was supposed to introduce Xeomin, a new direct competitor to Botox, at a major medical meeting in the US.


The FDA approved Merz Pharmaceutical's, Xeomin, in July 2010, which would compete with Allergan’s Botox in the treatment of facial wrinkles. Merz then began hiring employees in anticipation of selling Xeomin nationwide. The problem was they hired employees directly away from Allergan. These employees came to Merz with extensive knowledge and experience in the sale of Botox and Allergan's injectable fillers including sales lists, sales strategies, market analysis, competitive analysis etc. Reportedly, some Allergan employees signed contracts with Merz and then delayed giving final notice so they could e-mail company data to themselves. Allergan promptly initiated legal action on August 4, 2010 as hundreds of millions of dollars in sales per year were at stake.
 In response to this a Merz lawyer gave all sales representatives a presentation on compliance and confidential information at a national sales meeting on August 5, 2010. In this presentation, they were told, “Merz aesthetic prohibits employees from disclosing confidential/proprietary information of previous employers.” However, only 3 days before this, a regional sales manager for Merz sent out an e-mail that said: “Competitive info- For those of you coming from a competitor or former competitor, please give as much info as you can on KOL’S” (Key Opinion Leaders) sales numbers, office volume, product info etc… (SIC) this will be very valuable for everybody in the region.” The e-mail then noted that all of the recipients had been blind courtesy copied "...so that [they] would remain anonymous and exit [their] current positions without any problem." Eight days later, Merz's regional sales representative received Allergan documents labeled “For Internal Use Only” and “For Your Information Only. Do Not Duplicate, Detail, Distribute, or Use in Any Promotional Manner.” If this is not corporate espionage resulting in the looting of Allergan’s confidential and propriety information I do not know what is.

That means Xeomin will not be available to the general public until 2013 and Judge Guilford’s order will likely not put an end to this litigation. Furthermore a 12-month ban on Xeomin sales could put Merz out of business. The real losers in this battle are the medical community and the general public as an effective medication that has been FDA-approved and has both aesthetic and therapeutic value will be withheld for many months to come leaving Allergan with a near monopoly market position.

Allergan also prevailed in two separate cases that were filed against Merz in Europe. In Germany, the Hamburg Regional Court ruled that Merz is prohibited from claiming a 1:1 dose equivalent ratio between units of Botox (onabotulinumtoxinA) and Xeomin. In Spain, Merz was found to be in breach of the Spanish Pharmaceutical Code for referring to a conversion ratio without making an express warning about the fact that the unit doses are not interchangeable.

William D. Humphries, CEO of Merz Inc, state "We regret that this ruling will affect physicians and patients as we believe that access to quality FDA-approved treatment options, including Xeomin, is a cornerstone of the US market. It is critical at this juncture to clarify that this lawsuit, which is commercial in nature and focuses specifically on alleged trade secrets, did not call into question the quality of Xeomin."

Full compliance may allow for injunctive relief, at least in the US, after specific criteria are met, and enable the Merz to launch of XEOMIN in the US market.

Julio L. Garcia, M.D, a Las Vegas plastic surgeon, filed suit against Botox-maker Allergan at the end of 2011, claiming the Irvine California-based company sold the drug in large vials and encouraged physicians to unsafely reuse them. He contends that even though a typical Botox (onabotulinumtoxinA) treatment requires just 20 units, Allergan sold the drug exclusively in 100-unit vials for several years and that its sales reps encouraged physicians to use the vials on multiple patients. That practice is now condemned by the Centers for Disease Control and Prevention and state health agencies even though the majority of doctors still use a single vial on more than one patient. The suit, filed at the United States District Court, Central District of California, claims Allergan started selling Botox in 50-unit vials in 2008 “only after the hepatitis exposure in Nevada,” and that even with that revised packaging, the majority of the medication must be discarded after use, keeping costs and manufacturer profits high. Despite the common multiple patient use of vials a large amount of the medication is discarded daily because the shelf after reconstitution is only a few weeks.

November 13, 2012 Addendum:
Earlier this month the injunction filed in March was lifted permitting Merz to once again sell filler products Radiesse and Belotero. However the injunction against Xeomin, Merz's Botox equivalent, remains in place until at least January 9, 2013.


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Liposuction Can Result in More Fat Around Internal Organs

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Plastic Surgeon researchers at the University of Sao Paulo in Brazil followed 36 normal-weight women who had liposuction to take away a small amount of superficial tummy fat. Beginning 2 months after surgery half of these women were placed on an exercise program (walking on a treadmill and doing light strength training 3 times a week), while the rest stuck with their usual lifestyle. None exercised regularly before surgery.

Four months later the women who did not exercise still had flatter tummies, but they had 10% more fat around the organs inside the abdomen. The women who did exercise had no such gain in this visceral fat. This the the first study showing increases in visceral fat after liposuction if you do not exercise.
Visceral fat is particularly undesirable because it's more closely connected to the risks of type 2 diabetes and heart disease, versus the superficial abdominal fat just under the skin. Visceral fat is by its very nature more resistant to insulin than superficial fat under the skin. That means it more readily releases its fat in the form of free fatty acids into the blood stream. These free fatty acids then clog the arteries creating atherosclerosis, heart disease and high blood pressure and make the body insulin resistant over time.  Since even thin people who are not overweight can accumulate fat around their internal organs this explains why some diabetics are not overweight. Other studies have shown that removal of large amounts of subcutaneous fat from the abdomen by liposuction in diabetic and non-diabetic individuals does not improve insulin sensitivity in muscles, liver or fat, and does not change the blood levels of circulating inflammatory proteins. It also does not change blood pressure, blood sugar or insulin levels or the profile of fat/cholesterol in the blood. Lifestyle changes involving dieting and exercise however have been proven to incite these healthy changes in the internal milieu of the body.

You can also conclude from this that patients who are obese and try liposuction for weight control are actually endangering their health if they do not exercise or change their diets after liposuction because they will end up with even more fat around their organs. The best candidates for liposuction are normal weight to moderately overweight, and already regularly exercise. It is very important, if not essential, that patients exercise after liposuction.

In the U.S., about 204,700 people underwent liposuction in 2011, according to the American Society of Plastic Surgeons. That was down 42 percent from a decade before.

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Controlling Pain After Cosmetic Surgery

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Pain control during surgery has been quite good for a number of decades. Refinements in recovery from anesthesia to lower the incidence of nausea, shaking etc. after surgery have been accomplished by adjusting the mix of anesthetics used and employing newer medications like propofol, toradol, zofran etc. More recently the focus has been on controlling pain after surgery to lessen the need for narcotics, shorten recovery times after surgery and improve surgical results in general. The opioid narcotic medications commonly used can become addictive, have small windows between effective and overdosing quantities that affect breathing and tend to be constipating.
Local anesthetics have been in regular use since the late 1800s. Most people currently get their exposure to them at the dentist office where novocaine also called lidocaine is injected prior to dental work. The onset and duration of action varies between different local anesthetics. Novocaine is one of the quickest onset and shortest acting local anesthetics. About 10 years ago surgeons began using longer acting bupivacaine applied via external pumps and tubes like the on-Q system to the operative site as a means of pain control after surgery.
The thought was that slow constant administration of a long acting local anesthetic to the operative site would allow for a quicker recovery after surgery, allow the patient to get up and around earlier and decrease the need for narcotic pain killers after surgery. Their use became especially popular with orthopedic surgeons who would place the catheters directly over bones or into joint spaces after surgery (such as knee or shoulder surgery) and to a lesser extent with general and thoracic surgeons. In 2007 it was discovered that prolonged exposure of joints to local anesthetic caused permanent loss of cartilage in the shoulder joint and multiple lawsuits have been filed since. Currently, there is no effective treatment for cartilage loss; patients who have experienced it have required additional diagnostic and therapeutic procedures and some required arthroplasty or shoulder replacement. Use among plastic surgeons was more limited and confined mostly to tummy tuck and breast surgery patients to decrease reliance on pain medications and allow for earlier ambulation after surgery. I tried this in the past on tummy tuck patients and was unimpressed by its ability to do either so I stopped doing it.

In October, 2011 the FDA approved Exparel which has just recently become available for public use. Exparel is long acting bupivacaine that has been placed in a container of microscopic fat cells. The anesthetic is then slowly released from the fat cell container into the body after injection. This extends the effectiveness of the anesthetic from a few hours up to 3 days. EXPAREL is the first and only multivesicular liposome-based local anesthetic that can be used around surgery in the same fashion as current local anesthetics. The medication is injected near the end of surgery and should not be injected with other local anesthetics at the same time as that could result in sudden release of all of the anesthetic from the fat cell containers. In clinical studies exparel was most effective in the first 24 hours after surgery. The fat cell containers can be damaged by contact with the liquid antiseptics commonly used just prior to surgery.

Due to the large surface areas involved in body contouring surgery like breast surgery and abdominoplasty I suspect this medication will prove most useful for rhinoplasty, facial implant, ear and hand surgery. It will be especially useful for carpal tunnel and cubital tunnel surgery. Clinical studies have shown this medication to be most effective in the first 24 hours after surgery and to significantly reduce the need for narcotic pain medications after surgery.

I think we will see many more fat cell packaged medications in the future.

The Food and Drug Administration has also approved Pliaglis cream (lidocaine 7%, tetracaine 7%; Nuvo Research/Galderma), a new topical local anesthetic cream, to be used in superficial cosmetic procedures such as dermal filler injections, pulsed dye laser treatments, facial laser resurfacing and laser-assisted tattoo removals.
The cream uses a proprietary phase-changing technology to form a pliable peel on the skin when exposed to air. This is an improvement over previously applied topical anesthetic which required placement of the medication an hour or more before the procedure and a saran wrap like covering to ensure penetration and prevent evaporation. Pliaglis is applied for 20 to 30 minutes for most procedures, and for up to 60 minutes for more potentially painful procedures. Pliaglis® is available for patients exclusively through offices of licensed medical professionals.To avoid toxicity it should only be applied to up to 400 cm2 of intact skin for no more than 60 minutes.



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Nerve Freezing Alternative to Botox

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Botox has been available for decades to treat fine wrinkles on the face but this involves injecting minute amounts of a poison to temporarily paralyze the nerves. An estimated six million doses of botox are now given every year so it is now the single most popular cosmetic treatment in the United States. Now a revolutionary new concept is being developed to replace botox. It involves freezing the nerve so it is temporarily damaged and therefore paralyzed for an equivalent amount of time as the botox injection.


of Redwood City California has developed a system to freeze nerves. Hollow needles are super-cooled at their tips by being filled with a pressurized refrigerant and then inserted into the skin. The needle tip freezes the nerve over a 30 second interval without harming the skin or surrounding tissue. In clinical trials, the effect lasted between two to four months, roughly the duration of Botox injections. The system is still in the trial phase in the United States and not yet FDA-approved. However, it was recently cleared for treating wrinkles and muscle pain in Europe and Canada.

Again, this is very new technology. The company is currently opening its first centers in Europe where it received clearance early in 2012. The before and after photos that I have seen though are quite impressive.


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The Dangers of Sun Exposure

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In today's world the dangers of sun exposure as they relate to skin cancers and aging of the skin are common knowledge. The aging side of the issue was further supported by a case study published in the April edition of the New England Journal of Medicine. A patient seen at Northwestern Medical Center in Chicago was 66 years old on the right side of his face and 86 years old on the left side.

He had been a truck driver in Chicago for 30 years delivering milk to stores and gas stations between 6am and 3pm. Since the vehicle did not have air conditioning he kept the driver's side window open most of the time. After about 15 years of this he recalled always being more tanned on his left arm than his right arm.

Sunlight contains ultravioletA and ultravioletB light rays. The UVB causes sunburns and is blocked by glass and most sunscreens. UVA penetrates through glass and causes photoaging of the skin it is not blocked effectively by sunscreens that do not contain titanium dioxide or zinc oxide. Skin cancers can be caused by either UVA or UVB or both working together. This fact is why the FDA has made sunscreen labeling rules more restrictive. Only sunscreens containing titanium dioxide and/or zinc oxide can claim skin cancer prevention on their labels (as described in my 2008 blog Suntanning, Tanning, Sunscreens). If the Chicago truck driver had regularly used sunscreens his facial aging would have been more symmetric and his grandchildren would not be asking "what are these bumps, grandpa?" on the left side of his face.

Some 10 to 15 years ago I myself developed a precancerous skin lesion of the left lower eyelid near the nose. The southern California UVA penetrated through the driver's side door window bounced off my sunglasses hitting that area of the lower eyelid. I had it removed by laser so you cannot see where it was but have been bathing in sunscreen every morning since. I also had a patient who drove a truck in southern California for decades without sunscreen. Once he reached his late 50s early 60s he had had so much skin cancer surgery that he was missing parts of his ears and his face was a patch work quilt of skin grafts and flaps.

Suntanning, Tanning, Sunscreens

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Vampire Facelift is Really a Face Fill

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A google search on Vampire Facelift yielded 1,020,000 results. The term was first used by the press in a July 2010 ABC News report on the use of Selphyl for facelifting. Selphyl first became available in 2009 and involves taking a small sample of blood from the patient mixing it in a test tube to separate blood components, which takes about 20 minutes and then injecting some of the components (platelets) into the area to be filled. Your body then makes collagen to fill the depression or fold. The process takes about 3 weeks from the date of injection to become visible. Because the result was rejuvenating and the material came from one's own blood the term Vampire Facelift was employed. Although hyaluronate injectable fillers like Restylane had been around for 7 years at this point the injection of hyaluronate together with this platelet material began around this time.

A business wise endocrinologist in Alabama saw an opportunity in this and filed a trademark for Vampire Facelift in September 2010. He then marketed the term and courses to doctors on the double injection procedure and also developed a website for which he charged $97 monthly listing fees to those doctors. The charge for a course on doing the injections is $995 and that fee is waived if the doctor buys the $5995 "Vampire PRP System". The manufacturers of dermal filler injectables on the other hand give frequent symposium to doctors all over the US free of charge. This is off label use of both injectable fillers and the fillers are doing just that filling not lifting. This same doctor was reprimanded by the FDA in 2008 for not following proper investigational protocols with injections. In 2009 the Alabama Medical Board issued a cease and desist order to prevent him from injecting testosterone and thyroid hormone because of documented injections of the medications by him in cases where they were not medically indicated. After business discussions with the manufacturer to license the Vampire Facelift trademark collapsed Selphyl was replaced by another high platelet content solution in this injection process.

More recently he trademarked Vampire Breastlift. Now he advocates something called an O-shot where the same injection into female genitalia is proposed to increase sensitivity in the area and hence increase sexual desire and arousal as well as improve/increase orgasm. The next step was the Priapus Shot advocating the same injections into the penis to increase size, strength, circulation, sensitivity, pleasure etc.

If there was any credibility to this initially it was certainly lost after O-shot, Priapus Shot etc. It's no different than a snake oil salesman with an ever increasing number of indicated uses for their product. I would be very suspicious of this treatment methodology and anyone who uses it based on this history. I am not opposed to the treatment itself but the way it has been marketed and the misleading terminology employed in describing it. It is not a substitute for facelift surgery. Furthermore, congress outlawed the patenting of medical procedures some years ago so I do not see how this can be an enforceable patent.

Injectable Fillers

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Botox May Help Cancer Patients Recover Their Voice

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This is a guest post by Rod Kelly, a content writer for Cosmetic Surgery. You can follow Rod at @thefreshhealth :)

The botulinum toxin is widely recognized for its ability to decrease the appearance of wrinkles in cosmetic surgery. What many people may not know is that it also has a number of health benefits as well. Hospitals in India are currently using the drug as a treatment for cancer patients who have lost their voice due to throat cancer. Patients undergoing cancer treatment undergo a removal of the voice box as a part of the treatment necessary to remove the cancer.


Tata Memorial Hospital is one hospital that is currently performing the procedure on patients who are suffering with severe voice problems after cancer treatment. The treatment helps patients that are unable to benefit from an artificial voice box. For some patients, the treatment helps patients produce sound after doctors remove the voice box due to cancer. Ninety percent of patients who undergo the removal of their voice box will be treated successfully with an artificial voice box. For the remaining ten percent, the voice box does not restore sound.

The treatment is done by injecting the chemical directly into the vocal chords that will help in the muscle relaxation in order to relieve problems such as difficulty in speaking, stammering and strangled quality of voice. The frequency of the dosage required is determined by the doctor after a post-treatment checkup.

Patients must undergo tests to determine the cause of the prosthesis failure. If it is determined that a hyperactive or hypertonic pharyngoesophageal segment causes the artificial voice box failure, the Botox injection procedure can take place. The physician must also determine the length of the hypertonic segment. The injections are made into the segment at 1 cm intervals. Patients may see results in as few as 12 hours after receiving Botox injections.

Botox injections can also treat patients without cancer who have lost their voice because of laryngeal dystonia which causes the vocal chord to spasm. Physicians inject Botox into the muscles that surround the voice box to relax the muscles and allow vibration and sound to occur.

Botulinum toxin has been studied for more than 100 years and in the last 20 years a number of health issues have been treated with the neurotoxin. Botox has been used to treat cervical dystonia, muscle spasms, muscle pain and underarm sweating in addition to the treatment for voice box problems. There are currently 21 medical uses for the neurotoxin in 80 countries, with research continuing to uncover possible new uses.


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Groupon and Discount Coupons for Cosmetic Surgery

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Social media coupon sites such as Groupon and Living Social entice consumers to buy online coupons for products, services and procedures offered by a provider at a reduced price with the addition of a viral component in terms of likes and comments that appear on users facebook timelines.
These social media sites receive payment based on the number of consumer participants, and the arrangement generally brings higher-than-normal customer volume to the providers - in this case, plastic surgeons. However, some elements of this marketing should raise red flags with surgeons as well as patients, including:
  • Exaggerated language in the offering: Numerous sites use extreme exaggerations to garner attention
  • Lack of medical review: The only requirement the customer must meet is to purchase the coupon, which means that services or procedures are offered to potential patients without regard to medical suitability

A recent search on Groupon unearthed coupons that offer $4,200 worth of liposuction for $999 in Southern California; $3,500 worth of liposuction for $999 in Florida; $2,500 worth of liposuction for $999 in Michigan; and 20 units of Botox® for $250 in Ohio. In California (and several other states), laws prevent payments to physicians based on patient volume. Violating these laws can be punishable by prison and/or $50,000 in fines. In neighboring Oregon, the state's Board of Chiropractic Examiners and Board of Dentistry have prohibited their respective members from offering these types of discounts.

Many states have anti-kickback and ‘fee splitting’ rules for doctors. These rules forbid medical doctors from giving a payment to anyone for a referral. In other words, awarding a commission to an advertiser based on the income generated or number of patients treated is illegal. The use of Groupon violates those laws in California, Florida, Illinois, and New York State

Groupon has acknowledged that there may be issues with particular states and their licensing authorities, “Groupon advised [the American Society of Plastic Surgeons] through its counsel that it has not independently done a legal analysis and assessment as to whether the Groupon program violates federal or state laws regarding flee splitting, kickbacks, and referral fees.” Groupon does not consider it their obligation to determine whether these services are legal or not. “Groupon is taking a ‘buyer beware’ position and assumes no responsibility for determining whether the program raises legal implications for the service providers (doctors).”

In December 2011 British authorities banned an emailed ad from the “daily deals” website Groupon offering bargain rates on cosmetic surgery — including breast enlargements — and launched an investigation into the U.S.-based site. The ads offered discounts of well over 50 percent on operations at a Manchester clinic. The deal was for a cosmetic surgery procedure, “Such as Breast Augmentation and Rhinoplasty at Birkdale Clinic.” For £1,999 (just over $3000 US) consumers could receive £5,000 9 (about $7750 US) toward a breast or nose job (or other procedure), a very significant savings of 60 percent. The ban came after Britain’s Advertising Standards Authority received a complaint from the public and from the Independent Healthcare Advisory Service that the Groupon deal was irresponsible “because it encouraged recipients to hurry into a decision to purchase cosmetic surgery.” A Groupon statement denied that allegation, noting that the offer, available for only 24 hours, was made in conjunction with the clinic that provided the surgery, and that the tactic of a time limit was “an indicator of their business model and was not indicative of pressure purchase tactics.” Recipients of the email could click through to regulations that stated that purchasers had to be over age 18 and that an initial consultation was required before any procedure. The ASA pointed out that the marketing and ethical code established by the British Association of Aesthetic Plastic Surgeons prohibits ads that offer discounts linked to a deadline date for booking appointments. The practice also goes against General Medical Council guidelines. The ASA said the email promotion was irresponsible and banned it. The agency referred Groupon to the government’s Office of Fair Trade, which revealed it had launched its own investigation

Since most businesses using social media coupons realize the customer is only there for the bargain and will likely go away when the bargain is gone they try to sell them additional services not included in the coupon. They know they will not make any profit off the delivered service and there is a good chance it will not result in new referred business. Aside from upselling the only other option is delivering less than the actual service such as over diluting botox prior to administering it. Facebook has joined this online coupon craze with Facebook Offers.
The whole idea of social media discount coupons may be a bad business model as evidenced by the drop in share price of Groupon stock from $26 per share around the time of its IPO in 2011 to its current share price of $7.21 per share as well as publicized infighting between the founding partners over company direction. Facebook as well as dropped from over $40 per share near its IPO earlier this year down to $27.15.

January 10, 2013 Addendum:
The Medical Board of California filed a 94 page complaint against Dr. Efrain Gonzalez who is a non-plastic surgeon performing plastic surgery on unsuspecting patients in northern California. He lost his license in Puerto Rico in 2006 for practicing plastic surgery without being a plastic surgeon. The charges include gross negligence, incompetence and aiding or abetting the unlicensed practice of medicine in 15 patients. The injuries include damaging nerves to the hand paralyzing it during breast augmentation, leaving large uncloseable scalp wounds during hair grafting, mutilating the abdomen during abdominoplasty etc. Many of these patients when interviewed say they went to him for his low prices and Groupon deals. Now they are suffering the consequences.


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Mini Facelifts - LifeStyle Lift, QuickLift...

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Anyone watching television lately has been exposed to a mass marketing blitz by Lifestyle Lift. The infomercials claim over 150,000 completed surgeries and are filled with satisfied customers who in before vs. after photos look remarkably younger and happier after surgery. In 2012, Grammy®-winning singer, author, and television personality Debby Boone, best known for her 1977 RIAA Platinum-selling #1 hit "Theme from You Light Up My Life," became the spokesperson for the company in its television commercials and its half-hour infomercial; the song is well-represented in both the commercials and in the infomercial.

The ads promise “minor one-hour procedure with major results designed exclusively to improve jowls, frown lines, wrinkles, loose neck, and facial skin” that "requires no dangerous general anesthetic” and you can “return to work quickly compared to a traditional procedure.” They boast locations across the nation – in 42 cities and 22 states. The concept that is conveyed in this marketing is that this procedure is equally effective regardless of the surgeon doing it. Lifestyle lift is the company's name and is also a trademarked brand name used to market the procedure of the same name. Doctors sign up with the company and give a percentage of their fee to the company for performing their advertising. Prospective patients call the company or go to its website and are then referred to a nearby participating surgeon. The procedure itself is performed under local anesthetic and generally costs half the price of a regular facelift. Patients are lured in by the mass marketing, price and use of local anesthetic without general anesthesia (which is presumed to be riskier than local anesthetic). The model is high volume, low cost facelifting.

A regular facelift involves making an incision around the ear lifting or dissecting the skin off the underlying soft tissue in the neck and almost to the corner of the mouth. A variety of techniques are then employed to lift this deeper soft tissue of the cheeks and neck and the excess skin is removed from around the ear to yield the least noticeable skin scar, one that is hidden in the natural creases around the ears. Over many years after cumulative experiences of surgeons worldwide this became the standard facelift which gave the most reliable and longest lasting result.

Over the last few decades further modifications have been applied to the process to individualize it since no 2 people age exactly the same way. Beginning in the 1990s younger than previous patients began requesting the procedure. In these cases less aggressive surgery or only parts of the original procedure were necessary. The s-lift was born. In this procedure an s-shaped incision is made in front of the ear that extends under and in some cases around the back of the earlobe. The original s-lift involved a skin incision in front of the ear only and excising-suturing a deeper layer of tissue to give a tightening effect without elevating much skin as a separate layer by itself. The original procedure had little or no effect on rejuvenation of the neck. This was later modified by a number of physicians to include numerous different variations of the original procedure including pulling the deeper tissue upward using a suture tightened around the cheek bone. All are basically minor facelifts performed without doing all the steps of a full face lift. I personally do not use this misleading nomenclature as it gives rise to prospective patients asking for a specific procedure rather than asking for resolution of a specific cosmetic issue they want addressed. It has also facilitated incompletely trained or incompetent physicians to advertise their performance of specific procedures. They are incapable of going over the different procedures available with the patient much less performing those procedures. The lifestyle lift is basically an S-lift procedure with a neck tightening component including suturing tightening of a muscle in the neck. Instead of extending the skin dissection towards the mouth it is stopped a short distance from the ear and sutures with or without excision of deeper tissue near the ear are used to get a transmitted lift or tightening towards the center of the face beyond where the cuts are made. Some of the Lifestyle Facelift surgeons add procedures to the neck itself but in general  as a procedure Lifestyle Facelift adds nothing new to the armamentarium of facial plastic surgery techniques other than its marketing and reimbursement approach.  Other similarly trademarked lifts have appeared including "Quicklift", "The Weekend Facelift”, “The MACS Lift" etc. but none has been advertised to the extent of the Lifestyle Lift which has turned the procedure into a multimillion dollar business.

Almost since its inception LifeStyle Lift has been involved in multiple lawsuits. At one point the company sued Realself who had posted negative reviews as well as some positive reviews from LifeStyle Lift patients on their website. The allegation was that Realself infringed their patent by including the LifeStyle Lift name in their URL. Lifestyle Lift tried to use trademark law to wipe the negative reviews off RealSelf and keep them from influencing prospective consumers. Realself counter sued LifeStyle Lift for their employees allegedly placing false positive reviews on the Realself website. That case was settled with confidentiality agreements. Another company was sued by LifeStyle Lift for posting negative reviews on a webpage using a URL containing the term LifeStyle Lift again alleging patent infringement. The judge who heard the case dismissed it on May 2, 2008. In 2009 Lifestyle Lift reached a settlement with New York state over claims it had employees post false customer endorsements on third-party websites, including RealSelf.com, and on some 10 websites the company had created to appear as consumer generated praising of the procedure. Lifestyle Lift was ordered to pay $300,000 dollars to the state, and it agreed to cease the practice. In 2010, the Florida's attorney general office received more than 60 complaints about the company, including several contesting its claims about fast recoveries, minimal pain and results that take years off one's appearance. The office then opened an investigation to determine whether Lifestyle Lift's marketing practices constituted deceptive advertising by claiming its procedures were safer, less expensive, with faster recovery times than other types of facelifts. According to USA Today, Lifestyle Lift's advertising used the term "revolutionary" to describe a variation on longstanding face-lift procedures since the LifeStyle Lift did not really involve any new procedure other than the mass marketing of facelifts. In 2008, an Orlando, Florida facial plastic surgeon filed a complaint with the Florida Board of Medicine, seeking payment for emergency room services he provided to a Lifestyle Lift patient; the company denied that it was negligent in the case. The patient was "bleeding from the face" and needed emergency assistance with breathing and surgery for hematomas. The patient, who settled a lawsuit against Lifestyle Lift out of court, was in intensive care on a ventilator and breathing tubes for six days. Since the complications were the result of cosmetic surgery her insurance presumably did not cover the emergency room care, the surgeon was forced to treat the patient by federal laws and she likely had no more money after the lift procedure so the surgeon could only get reimbursed by LifeStyle Lift. In July 2009 a Massachusetts woman had a seizure during the procedure presumably from the local anesthetic injection, was not hooked up to any continuous-monitoring equipment during the procedure, and no anesthesiologist was present. The medical staff did not know immediately how little oxygen she was getting. Forty-eight minutes after her first injection, the staff called for an ambulance. She was taken by ambulance to Mount Auburn Hospital in Cambridge,Massachusettes where her heart stopped twice and she was diagnosed as brain dead; she was deprived of oxygen for far too long. Her family took her off life support a week later and is now suing for wrongful death.

Now that there is blood in the water the sharks are circling and Meyerkord & Meyerkord, a St. Louis based personal injury and medical malpractice law firm, announced it is currently investigating claims related to the Lifestyle Lift® cosmetic procedure in pursuit of a class action lawsuit.

A Fort Myers, Fla., facial plastic surgeon, says he's treated several patients who were unhappy with the results they got at Lifestyle Lift. Most had "visible, poorly executed face-lift scars with no discernible aesthetic improvement," he says. USA TODAY interviewed six other plastic surgeons who did not want their names used but made similar comments.

The photography used in LifeStyle Facelift marketing is filled with variability using different angles, lighting, brightness settings, position, glamour shots, and laser treatments. The captions and narration often suggest some patients achieved the results in “about an hour procedure” under only local anesthesia. This is obviously false in many of the displayed cases. These practices may mislead thousands of prospective patients and use fear mongering of anesthesia as a selling point.. Disclaimers have recently been added to the marketing stating in fine print that patients pictured may have had “more extensive procedures.” This may have been in response to some of the litigation described above.

Although a min-facelift, LifeStyle Lift or other type of lift, may appropriate in some patients it is not appropriate for all patients just as local anesthesia alone is not appropriate for all patients. A great many of these procedures are performed under local anesthesia in non-certified operating rooms which can be very dangerous should the patient develop a problem during surgery. Although some patients are happy with the process and the results many patients complain of difficulty in seeing the surgeon after surgery, having legitimate complaints ignored, referrals to a national LSL complaint center and minimal contact with the surgeon prior to surgery as their presurgery care was provided by consultants. One of the top complaints is the lack of longevity of the procedure. Realself.com has gathered data from thousands of LifeStyle Lift patients, and found a 42% dissatisfaction rate, which is far higher than that described for private-practice independent plastic surgeons. The highly variable reviews of the LifeStyle Lift could be due to a one size fits all approach (the procedure is not for everyone), false positive reviews by the company (as they have a history of doing so), differences between actual surgeons or some combination of the above. Surgeons involved with the LifeStyle Facelift corporation have reported that there is corporate pressure to maximize conversion of consultations to surgeries. The ads would have you think that all surgeons performing a LifeStyle Lift and advertised on their website are the same but we all know that is not the case. It is the surgeon that is important not the name of the procedure performed or machine used at surgery just as it is the tennis player not the racquet that wins the tennis match.

Critics call this the commoditization of cosmetic surgery. Procedures that once included lengthy consultations with plastic surgeons and trips to the hospital, now often involve meetings in office-park surgery centers with salespeople who tell prospective patients what "work" they need and how little it can cost when performed in their offices as opposed to a private plastic surgeons office. The patients are pulled in by aggressive marketing programs on television the internet etc. This started some years ago with hairgrafting in the Bosley clinics and has spread to liposuction, facelifts, laser treatments and god knows what else. Proponents claim this way of doing plastic surgery allows those who otherwise would not be able to afford it to undergo cosmetic surgery.

While these clinics may employ plastic surgeons who are either board-certified or up for certification, lawyers, victims and other plastic surgeons say these new-style surgery clinics are under so much sales pressure they often don't sufficiently screen patients for medical problems, do inadequate follow-up and persuade patients to undergo procedures that are either unnecessary or unlikely to get good results. The surgeons work there because they have few other options in a long term recession where few have access to money and their case loads are disappearing to these heavily marketed companies offering steeply discounted procedures. I have personally witnessed this with one company who offered to hire me for liposuction procedures under only local anesthesia but would not let me see the facility until I signed a non-disclosure agreement. The facility had poor patient follow up, substandard operating facilities lacking emergency equipment, inadequate consent forms and other paperwork and high rates of patient dissatisfaction requiring revision. When I broached some of these issues I was suddenly persona non-grata and none of my calls or emails were answered. After some prodding they told me the job opening had basically dematerialized.

3 business models have arisen in this commoditization process. The first involves the surgeon working in the companies facility as an employee as in the Bosley model for hairgrafting and the Sono Bello model for liposuction. The second involves the surgeon using their own office to see referred patients like the LifeStyle Lift and Vampire Facelift. The third involves the company referring patients and stationing their own employees in the doctor's office like the American Laser Clinics. The end result to the practice of Plastic Surgery though is just as destructive.

Awake Surgery
Face and Neck Lift 1
Face and Neck Lift 2
Vampire Facelift is Really a Face Fill

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Systemic Lupus Erythematosus (SLE) and Cosmetic Surgery

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Lupus is a rheumatic condition which affects the muscles, joints, and connective tissue. About 1.5 million people in the US have lupus which includes as many as 10,000 children. Nearly 90% of those diagnosed with lupus are female. It's an autoimmune disease. A healthy immune system produces special proteins or antibodies and these normally protect the body against bacteria and viruses that cause infections. In the case of lupus, the immune system confuses the body's healthy cells and sees them instead as if they were a bacteria or a virus, and the result is that our antibodies then attack some of our own body's healthy cells. You become allergic to yourself.


So, what causes lupus? The cause is unknown although genetic factors may be important. Certain things can trigger the disease such as infection, medications, and even extreme physical or emotional stress. There are different types of lupus; the commonest is something called systemic lupus erythematosus or SLE and this affects multiple organs, and there is also form known as discoid or cutaneous lupus which only affects the skin, and in as many as 10% of all lupus cases, they're classified as drug-induced lupus.

Systemic Lupus Erythematosus (SLE) is an autoimmune disease where self generated antibodies attack different organs systems in the body including blood vessels, liver, eyes, kidneys, joints, heart, heart valves, skin, lungs, brain...and/or form complexes with their protein targets (antigens) that damage these organ systems. The degree of damage to each organ system is highly variable. Arthritis and joint pain is the most frequent complaint. It is thought to be due to a genetic predisposition combined with viral infections. The disease can spontaneously remit, respond to corticosteroids or be unresponsive to available medications. 50% of those with SLE have some degree of heart and/or kidney involvement. Much of this organ damage can be masked and then suddenly become apparent especially during flare ups of the disease. I am aware of one women in her 30s who died in the recovery room after breast augmentation by another surgeon due to a heart attack caused by SLE induced damage to her coronary arteries.

So, what are the symptoms that are commonly associated with lupus? There are many. Classically, there will be butterfly rash. This is a rash that is across the cheeks and the bridge of the nose. There may be sensitivity to light that results in a rash. Also there can be ulcers in the nose or mouth, which are usually painless. There's a long list of many other symptoms that are associated with lupus including things like arthritis, inflammation of the lining around the organ such as the heart and the lungs, kidney problems. There may also be neurological disorders including problems with seizures or even psychosis. Blood problems and problems with the immune system are also found in lupus. And in addition to that, there are some nonspecific symptoms such as fever, weakness, fatigue, and weight loss. There is no known cure for lupus but the symptoms can be controlled with drugs, for example steroids, and sometimes more aggressive treatment is needed with immunosuppressive therapy.

Therefore it is imperative if you have systemic lupus that you have a complete examination of all major organ systems before undergoing any elective cosmetic surgery. This may include cardiac stress testing and blood tests for liver and kidney function. If you cannot be weaned off of prednisone that may be an ominous sign and may preclude any elective cosmetic surgery especially if any implants are involved.

If you are taking prednisone for lupus the medication can also prolong the healing time after surgery and weaken your ability to fight infection so proceed with caution before undergoing any elective cosmetic surgery.

For detailed information, support groups and to live the fullest life that you can with lupus visit the Lupus Foundation of America and the Lupus Research Institute.


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Finding a Breast Augmentation or Related Procedure that Works for You

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This is a guest post by&nbspPeter Samberg, writer forAssociates For Plastic Surgery- A Leader in San Diego Breast Augmentation.

Every year hundreds of thousands of women undergo breast surgery. Many of these are cosmetic procedures that utilize breast implants. The surgeries are performed by plastic surgeons. Generally, breast augmentation surgery is designed to increase the size of small and underdeveloped breasts.

Pregnancy and breast feeding can decrease breast volume
Breast surgery can also restore or enhance breast volume. The size of a woman's breast will sometimes decrease as a result of pregnancy or breast feeding. Additionally, breast implants can serve numerous other purposes.


Breast cancer, asymmetrical breasts and deformity
It is not uncommon for breast cancer victims to use implants in conjunction with reconstructive surgery after a mastectomy. Another common issue is women with asymmetrical breasts that need an implant to help balance the difference in size. Breast surgery can also help to correct deformed breasts.

Types of breast implants
The type and size of breast implants that will be recommended for you will be determined largely by your personal objectives. Things that you and your plastic surgeon will take into consideration will be your existing body frame and associated mass, your existing breast tissue, and the preferences you have. Breast implants use a solid silicone rubber outer shell which is called a lumen. The two typical implant options include:
  • Silicone breast implants that are pre-filled with soft, elastic gel.
  • Saline breast implants that arefilled with sterile salt water at the time of surgery, or they can be pre-filled. 
The location of the incisions
Depending on several factors, an incision can be made underneath the breast, just above the crease, around the lower edge of the areola or within the armpit. With some procedures the surgeon can enter through the naval. Saline-filled implants often require a smaller incision since they are filled with saltwater after the implant is inserted. In some cases the incision is less than one inch in length and is relatively inconspicuous.

Listed below are other related breast surgery procedures:

·       Breast reduction
·       Breast reconstruction
·       Breast lift surgery

Your surgeon will help you find the procedure that works for you
Naturally, surgical techniques for breast augmentation, the use of breast implants, and the other surgical procedures such as the ones listed above are always being refined and improved. Over time, the safety and reliability of the procedure continues to increase. As additional options are made available, your plastic surgeon will provide you with the most recent information. They will help you to find the right surgical procedure for you.

Image credit: www.freedigitalphotos.net


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New Type of Breast Implant - The Ideal Breast Implant

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The 2 main types of breast implants available for decades have been the saline filled an silicone gel filled breast implants. Each has its pros and cons. Silicone gel implants have a more natural feel and look. Unlike silicone gel, implants containing only saline do not blend well with surrounding tissues at the edges of the implants. This is due to the chemical properties of salt water which is chemically charged as positive and negative charges that attract each other as opposed to silicone gel which does not carry a charge. Thus saline is more cohesive than silicone. What this means in clinical terms is that saline implant margins are more visible than silicone gel implant margins, especially when the soft tissue (breast gland and fat) between the outside world and the implant is thinner. Thus, in those patients with smaller breasts (less glandular tissue and/or fat) it is preferable to place saline implants under the chest muscle.

Saline implants may look very good when lying flat on a table. However, when upright the upper portion of the implant collapses (wrinkles or ripples) as the cohesive saline falls to the bottom of the implant and cannot support the upper part of the underinflated implant. If this underinflated implant is placed on top of the muscle in a thin individual with small breasts the collapsed upper part of the implant can be very unsightly. The collapsed edges appear as rippling when viewed from outside the body. The rippling becomes more apparent after the postoperative swelling resolves and the pocket around the implant shrinks to meet the dimensions of the implant. When placed submuscularly the rippling is more apparent to the side of the chest wall and lower chest, where there is no muscle, and when leaning forward because this positions the implant closer to the surface. Overfilling a saline implant (above the amount listed on the box) on the other hand can also be unsightly & doesn't necessarily prevent the appearance of wrippling. Overfilling produces a hard breast which most patients seem to like less than rippling. Despite this some patients prefer saline because they are worried about leakage of silicone gel. Since the saline implants are inflated after placement they can be inserted through a much smaller incision than silicone gel implants and can be fine tuned for size and breast symmetry as they do not come pre-filled.

For years double lumen implants of saline and silicone gel were available in attempt to have a breast implant that was the best of both worlds. The implants had an adjustable saline bag inside a silicone bag.
They were available in 50/50, 25/75 and 35/65 percentage ratios of silicone gel to saline. I have recently been informed by the manufacturers that they no longer make this type of implant.

In 2006 a new saline implant was designed to improve the results obtainable with saline implants. It is called the Ideal Implant and contains an inner shell defining an inner saline compartment and an outer shell defining an outer saline compartment; between these shells are one to three unattached, perforated shells.
This internal structure was designed for control of saline movement to reduce bouncing, and for support of the implant edges to minimize wrinkling and prevent collapse of the upper portion of the implant. In the photo below you can see less collapse of the upper half of the Ideal Implant when it is upright.
The edges of the implant were also lowered so it may contour better to the chest wall.

FDA clinical trials were then begun and closed to new patients in 2010. The studies will last 10 years but the 2 year results have just been released and are favorable. Two-year follow-up visits were completed by 472 of the 502 women enrolled at 35 private practices. Of these, 378 had undergone primary breast augmentation and 94 had received replacement augmentation. Patient-reported satisfaction with the outcome was 94.3% for primary augmentations and 92.3% for replacement augmentations. Moreover, surgeon-reported satisfaction was also high (96.5% and 93.4%, respectively). The incidence of moderate-to-severe wrinkling was 3.8% (primary) and 12.0% (replacement). Baker Grade III and IV capsular contracture rates were 3.8% (primary) and 8.2% (replacement). These 2-year rates are lower than those reported for current standard single-lumen saline implants at 1 year. It will still be a number of years before these are available to the general public but it looks promising so far.

A Natural Look with Breast Implants
New Discovery Could Make Breast Implants Obsolete

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Laser Tattoo Removal

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Tattoos have been applied to human skin for thousands of years. In 12,000 B.C. ash rubbed into skin cuts at bereavement ceremonies. Tattoo pigment bowls and needles have been found in Western Europe dating back to 8,000 B.C. Egyptian mummies have been found dating back to 4,000 B.C. that have tattoos as well as evidence of attempted removal. In 543 A.D. the Greek Aetius first documented the attempt at tattoo removal using salabrasion (abrasion of the skin with salt).

In modern western cultures tattoos can be barriers to employment, perceived as antisocial or aggressive behavior or signs of immaturity, rebellious behavior or inability to accept authority.

Over time the tattoo ink particles move deeper into skin and become duller, indistinct and blurred. Older tattoos are harder to remove in part because the ink particles move deeper into the skin over time. The ink depth and density is highly variable within a tattoo i.e. tattoos are not uniform.

In the late 1970s laser tattoo removal appeared on the scene after different wavelength lasers became available and it was shown that the tattoo inks selectively reflected or absorbed different wavelengths of light. The selective heating of the ink over adjacent skin cells by the laser broke up the ink particles and allowed cells within the skin to remove these smaller ink particles. In 1983 Reit et al described the use of shorter laser pulse duration using a Q-switch (nanoseconds rather microseconds) resulted in less surrounding tissue damage, multiple lesser treatments gave better results than single large treatments and the need to space treatments 3 or more weeks apart to allow for tissue recovery between treatments and pigment removal by skin cells. Black and red inks absorb the wavelength of light emitted by the Q-switch laser better than other colors.
Removal of a larger than 12inch arm tattoo using a Q-switched Nd/Yag laser.


Currently as many as 22% of U.S. college students have at least one tattoo and about half of people who get tattoos later try to have them removed.

A new study from a laser-surgery center in Milan, Italy, looked at 352 patients treated from 1995 through 2010. They found that tattoo removal is less likely to succeed if the person is a smoker, the design contains colors such as blue or yellow and the tattoo was larger than 12 inches.
Smoking reduced by 70% the chance of successfully removing a tattoo after 10 treatment sessions. Smoking is believed to hinder tattoo removal because smoking is known to hinder wound healing. Overall, the study found about 47% of people had their tattoos successfully removed after 10 laser treatments and it took 15 treatments to remove tattoos from 75% of patients.

The researchers also found that the amount of time between Q-switch laser treatment sessions was important to the technique's success. Treatment intervals of eight weeks or less were found to be less effective for tattoo removal so waiting more than 2 months between treatment sessions is a good idea.

A separate study, also published in the Archives of Dermatology, however, suggests a different type of laser currently in development called a picosecond alexandrite laser, can remove tattoos with fewer treatments than the Q-switch laser. No word yet as to when this will be commercially available.

Laser Tattoo Removal

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Plastic Surgery in South Korea

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According to a International Society of Aesthetic Plastic Surgeons survey the top 3 countries in the world in terms of the number of people in the country having plastic surgery are the United States, Brazil and China. Over 3.3 million plastic surgery procedures were performed in the US, 2.5 million in Brazil and 1.27 million in China in 2010. When you look at plastic surgery per capita to correct for the size of the population the picture is quite different. South Korea had the most per capita in 2010 with 16 procedures per 1,000 people. Half of them had non-invasive treatment including botox and facial peels. Next came Greece with 14 procedures per 1,000 population, followed by Italy, Brazil, Colombia, the U.S., Taiwan, and Japan.

According to a 2009 survey conducted by market researcher Trend Monitor one in every five women (20% of the female population) in Seoul between the ages of 19 and 49 said they had undergone plastic surgery. So many women have had surgery that Korean film casting directors now have trouble finding female actors for historical films. There are so many plastic surgeons per capita in South Korea that it is driven down the price of surgery forcing many surgeons there to operate at least part time in nearby countries like China. Plastic surgery clinics compete by giving away free surgery to women who then must blog about there experience before, during and after surgery. These blogger ambassadors have to blog about their "beauty enhancement journey" for 5 years. The American Society of Plastic Surgeons on the other hand has a rule against its members trading free surgery for advertising endorsements.

No wonder South Korea has a Miss Plastic Surgery beauty contest. Last year's 22 year old winner regularly talked about the procedures she had, sometimes disappeared for days presumably to recover from surgical bruising and swelling and refused to name the clinic where her surgery was performed.`This led to accusations that the procedures were performed in a minor clinic or out of the country. Then someone uploaded pictures from her school yearbook revealing that she had not had any surgery since the photos were taken. She then came clean that she never had surgery and that "it's amazing what you can do with a bit of makeup". She had to give back her title and other contestants are planning to sue her. On the other side of the coin the Miss Korea 2012 shocked Koreans when early photos appeared revealing that she had definitely had plastic surgery. Despite that it does not look like she will have to give back her title.

Korea also has an increasing plastic surgery medical tourism industry with 70% of patients coming from China. Hotels, such as the Ritz-Carlton Seoul,opened with their spa partner Possom Prestige in December 2011, have partnered with hospitals to offer a US$88,000 "anti-aging beauty package,".  In 2011 foreigners arriving in South Korea for medical tourism contributed $116 million to the South Korean economy. The international boom is fairly recent, beginning in earnest in 2009 when the Ministry of Health first granted local clinics official permission to receive foreign patients. The government imposed a 10% tax on five popular types of cosmetic surgery in July 2011. Also in 2011 the Education Ministry issued a booklet warning Korean high school students of 'plastic surgery syndrome', citing Michael Jackson and a local woman whose addiction to plastic surgery left her with a grotesquely swollen face.

The International Society of Aesthetic Plastic Surgeons survey also revealed that there there were local preferences for certain procedures. There are seven times more buttock operations in Brazil than the top-25 country average, and five times more vaginal rejuvenations. In Greece, penis enlargements are performed ten times more often than the average, with 592 such procedures carried out during 2010. The rate of nose jobs per capita in Iran is seven times that in the United States.


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Remove Stretched Ear Piercing

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The stretching of body piercings has been practiced for thousands of years presumably beginning shortly after humans started wearing jewelry. Mummified bodies with stretched earlobes have been discovered, including the oldest mummified body discovered to date: Ötzi the Iceman (3300BC). Gautama Buddha, an aristocratic and wealthy prince, had long stretched ears. He wore heavy gold earrings or precious stones as a status symbol, and the weight stretched his ear lobes dramatically. When he finally renounced his wealth and discarded his jewelry, his ear lobes were permanently stretched. As a way of remembering Buddha's act of personal self-sacrifice in walking away from his wealth, all succeeding images of Gautama Buddha show his stretched ear lobes without jewellery. Ancient Egyptian pharaoh King Tutankhamen is of one of the earliest known to have stretched ear lobes. It can clearly be seen in one of his more famous images on his sarcophagus. African, Eurasian and American indigenous peoples did and do so for cultural, religious and traditional purposes.

Modern day teens and 20 somethings are also stretching their ear piercings in vast numbers.

Instructions for doing so including instructional videos can easily be found on the internet. I recently received a call from a distraught father who tore his teenager's stretched ear piercing during a heated argument over it. Eventually most individuals grow out of the desire for enlarged piercings, many do so for job or social reasons.

Dr Snell, of the Royal Adelaide Hospital Department of Plastic and Reconstructive surgery, in Australia has come up with a novel way to treat the problem.
The bottom ring of the opening is rolled to fill the hole.

Closure of a 4cm Opening Using This Method



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Rhinophyma - Acne Rosacea

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Rhinophymas have been observed for centuries but the term rhinophyma (from the Greek rhis for nose and phyma for growth) was first used in 1845 by Hebra. It was initially thought to be due to chronic alcohol consumption but is currently thought to be a severe form of acne rosacea. There is bulbous enlargement of the nose with a ruddy complexion and numerous pits along the surface. The sebaceous glands of the nose increase in size and number with each surface pit being the mouth of a gland. Although the disease is benign superficial skin infections are characteristic with drainage of foul smelling material. It is 12 times more common in men than women.
In the early stages accutane may help shrink the sebaceous glands but could adversely effect future surgical treatment of the disease. For more marked disease the treatment is full thickness excision with skin grafting or tangential (partial thickness) excision allowing the skin to heal without grafting. Some surgeons prefer laser excision citing less bleeding among other reasons. Having seen and tried various modalities I think tangential excision with a scalpel under local anesthesia is best. The nature of laser excision makes this more difficult with laser which works from the surface downward rather than tangentially.

The nose heals within a week or 2 as the surface is repopulated by cells from the depths of all those pits. After it heals over the nose will be red for some months. This redness resolves on its own but its resolution can be quickened with the use of a flashlamp laser, application of topical steroid cream or covered in the interim with makeup.

Since the disease is not curable control in the early stages or after surgical excision and healing is of paramount importance to prevent recurrence. This involves continued use of oral tetracycline antibiotics at least a few times a week or topical application of metrogel antibiotic and meticulous skin cleansing. This prevents recurrence but is of no use in treating or decreasing the size of an existing rhinophyma. Avoidance of spicy foods, caffeine and alcohol also may help.

Rhinophyma

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Reconstruction After Breast Cancer Surgery

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Breast cancer forms in tissues of the breast, usually the ducts (tubes that carry milk to the nipple) and/or lobules (glands that make milk).

It existence was acknowledged thousands of years ago. The ancient Egyptians in 1600BC described it as a “coagulum of black bile” within the breast and thought that getting rid of the excess bile¬ — through surgery, special diets, purging or even attaching leeches to draw out the bad blood— could cure the disease. In 1889, American surgeon William Halsted, a founder of renowned Baltimore teaching hospital Johns Hopkins, performed the first radical mastectomy removing the breast and underlying chest muscle in an attempt to cure the disease. It was not until the introduction of breast implants in 1963 that any reasonable breast reconstruction could be performed.

October was breast cancer treatment awareness month and currently the United States has the world’s highest breast cancer survival rate. Americans have a nine percent higher breast cancer survival rate than Canadians, 9 percent higher breast cancer survival rates than Germany and 15 percent higher than England. Aside from non-melanoma skin cancer, breast cancer is the most common cancer among women in the United States. It is also one of the leading causes of cancer death among women of all races and Hispanic origin populations. However, breast cancer death rates have been declining since the early 1990s for all women in the US except American Indians/Alaska Natives, among whom rates have remained stable due to screening and early diagnosis.

It is a disease that effects rich and poor. Celebrities like Sheryl Crow, Christina Applegate and Sharon Osbourne have had breast cancer surgery. The surgery involves
  • removing the part of the breast containing the cancer, 
  • removing all of the breast containing the cancer (mastectomy) or 
  • removing the breast in a women at high risk for developing a breast cancer (prophylactic mastectomy). 
It is followed in many cases by chemotherapy and/or radiation therapy. Some surgeons will spare the nipple in certain cases. Once removed the plastic surgeon is called upon to make a new breast i.e. reconstruct the breast and if necessary the nipple. Reconstruction can be “immediate,” performed at the same time as the mastectomy, or “delayed,” performed in a separate surgery later. From the late 1990s to the late 2000s, the rate of immediate reconstruction after mastectomy increased from about 21% to 38%--an average increase of 5% per year. The field of breast reconstruction has made major advances over the last 25 years. The reconstruction can involve
  • a breast implant or
  • use the patient's own tissue i.e. fat from elsewhere on the body (abdomen, hips, buttocks or thighs) or
  • a combination of the patient's own tissues and a breast implant.
Breast reconstruction is currently very different than it was in 1963 when breast implants were first introduced and currently include:


Tissue expander reconstruction with later replacement of expander with an implant.
Latissimus dorsi (LD) muscle from the back moved to the front with or without an implant.

TRAM flap moving lower abdominal skin and fat to the chest
Free flap reconstructions where skin and fat from the lower abdomen or elsewhere on the body is moved to the chest and the blood vessels attached in their new location.

From the late 1990s to the late 2000s, the rate of immediate reconstruction after mastectomy increased from about 21% to 38%. During this period, the number of reconstructions using the patient's own tissues remained relatively unchanged but the rate of reconstructions using implants increased by an average of 11% per year. Before that TRAM flap reconstructions were the most popular means of reconstruction. Part of the reason for this was more patient's were having both breasts removed and did not have enough of their own tissues to make 2 new breasts. Also patients with non-private health insurance (Medicare) are more likely to have implant reconstructions and over time the percentage of patients on Medicare is going up.

The overall complication rates are similar for the 3 common types of flaps used during breast reconstruction, but the types of complication, resource use, and costs differ. Looking at patients who received free flap, latissimus dorsi (LD) flap with implant or expander, or transverse rectus abdominus myocutaneous (TRAM) flap breast reconstruction during the first 6 months of 2008 it was noted that TRAM flap reconstructions were associated with the highest return rates for the treatment of complications, LD flap reconstructions were associated with the highest return rates for procedures that were not related to complications, and free flap reconstructions were associated with the highest total costs within the first 18 months after surgery. The rates of diabetes, smoking, and obesity were the same in each group of patients. Complications related to the implant, graft, or mesh were higher with the LD flap (19%) than with the free flap (11%) or the TRAM flap (10%) (P = .004). Hematomas and seromas were more frequent with the LD flap (6%) and TRAM flap (5%) than with the free flap (2%) (P = .04). Skin/fat necrosis was more frequent with the free flap (8%) and TRAM flap (6%) than with the LD flap (2%) (P = .006). Wound problems were more frequent with TRAM flap (6%) than with free flap (3%) or LD flap (1%) (P = .01). Consequently the LD flap patients had the highest surgical revision rate and the TRAM flap patients had the highest complication rates requiring return to the operating room.

The average cost of breast reconstruction was $40,079 per patient. The cost for free flaps was $56,205, for TRAM flaps was $33,380, and for LD flaps with implant/expander was $30,783.

Looking at the average cost per patient for specific complications, the highest was for the treatment of infection with a TRAM flap ($2529), followed by the treatment of an implant-related complication with an LD flap ($2145).

In the early 1990s health insurance companies began denying coverage for breast reconstruction surgery citing that the cancer was medically necessary but the reconstruction was not. It took an act of congress passed in October 1998 (Womens' Health and Cancer Rights Act) requiring group health plans and health issuers that provide medical and surgical benefits with respect to medically necessary mastectomy for breast cancer, to cover the cost of reconstructive breast surgery for women who have undergone a mastectomy. The law states:
  • The attending physician and patient are to be consulted in determining the appropriate type of surgery.
  • Coverage must include all stages of reconstruction of the diseased breast, procedures to restore and achieve symmetry on the opposite breast and the cost of prostheses and complications of mastectomy, including lymphedema.
This law should ensure that the insurance companies will not be able to force patients to choose reconstructions just because they are cheaper. Despite this 70% of women eligible for reconstructive surgery after mastectomy in the US are not fully informed of their reconstructive options. Women who get reconstruction are more likely to go back into the work force, are less likely to be reclusive and more likely to go back out and do what they used to do.

Breast Cancer Statistics US

  • Estimated new cases and deaths from breast cancer in the United States in 2012: New cases: 226,870 (female); 2,190 (male) Deaths: 39,510 (female); 410 (male) About 1 in 8 U.S. women (just under 12%) will develop invasive breast cancer over the course of her lifetime.
  • In 2011, an estimated 230,480 new cases of invasive breast cancer were expected to be diagnosed in women in the U.S., along with 57,650 new cases of non-invasive (in situ) breast cancer.
  • About 2,140 new cases of invasive breast cancer were expected to be diagnosed in men in 2011. A man’s lifetime risk of breast cancer is about 1 in 1,000.
  • From 1999 to 2005, breast cancer incidence rates in the U.S. decreased by about 2% per year. The decrease was seen only in women aged 50 and older. One theory is that this decrease was partially due to the reduced use of hormone replacement therapy (HRT) by women after the results of a large study called the Women’s Health Initiative were published in 2002. These results suggested a connection between HRT and increased breast cancer risk.
  • About 39,520 women in the U.S. were expected to die in 2011 from breast cancer, though death rates have been decreasing since 1990 — especially in women under 50. These decreases are thought to be the result of treatment advances, earlier detection through screening, and increased awareness.
  • For women in the U.S., breast cancer death rates are higher than those for any other cancer, besides lung cancer.
  • Besides skin cancer, breast cancer is the most commonly diagnosed cancer among American women. Just under 30% of cancers in women are breast cancers.
  • White women are slightly more likely to develop breast cancer than African-American women. However, in women under 45, breast cancer is more common in African-American women than white women. Overall, African-American women are more llkely to die of breast cancer. Asian, Hispanic, and Native-American women have a lower risk of developing and dying from breast cancer.
  • In 2011, there were more than 2.6 million breast cancer survivors in the US.
  • A woman’s risk of breast cancer approximately doubles if she has a first-degree relative (mother, sister, daughter) who has been diagnosed with breast cancer. About 15% of women who get breast cancer have a family member diagnosed with it.
  • About 5-10% of breast cancers can be linked to gene mutations (abnormal changes) inherited from one’s mother or father. Mutations of the BRCA1 and BRCA2 genes are the most common. Women with these mutations have up to an 80% risk of developing breast cancer during their lifetime, and they are more likely to be diagnosed at a younger age (before menopause). An increased ovarian cancer risk is also associated with these genetic mutations.
  • In men, about 1 in 10 breast cancers are believed to be due to BRCA2 mutations, and even fewer cases to BRCA1 mutations.
  • About 85% of breast cancers occur in women who have no family history of breast cancer. These occur due to genetic mutations that happen as a result of the aging process and life in general, rather than inherited mutations.
  • The most significant risk factors for breast cancer are gender (being a woman) and age (growing older).
  • As of Jan. 1, 2009, there were about 2,747,459 women alive in the United States with a history of breast cancer. This includes women being treated and women who are disease-free.

Breast Cancer Statistics Canada

  • Breast cancer is the most common cancer affecting women in Canada.
  • One in nine women is expected to develop the disease during her lifetime, according to the Canadian Cancer Society. Last year, 23,400 women were diagnosed in Canada.
  • But fewer women are dying from the disease, likely due to increased screening and improvements in treatment. The current five-year survival rate in Canada is 88 per cent.
  • The mortality rate is the lowest it has been since 1950, according to the cancer society.
  • In 2010-’11, a total of 24,735 women had mastectomies in Canada, according to the Canadian Institute for Health Information. Of those, just 945 women — about one in 26 — had immediate reconstruction. Only 1,719 women — about one in 15 — had delayed reconstruction. In 2006, fewer than 10 per cent of Canadian women who had mastectomies also had reconstruction.

The Belinda Stronach Chair in Breast Cancer Reconstructive Surgery was created at Toronto General Hospital in November 2007. However as of 2012 no one has been appointed to the position. The delay is due to lack of funding in that after 5 years only half of the required money had been raised. However some of the funds have gone towards research, training fellowships for surgeons and patient education. Few surgeons in Canada do the more extensive procedures because of poor reimbursement.

Breast Cancer Statistics UK

In 2009 21% of mastectomy patients underwent immediate breast reconstruction.

See the online booklet What You Need To Know About™ Breast Cancer to learn about breast cancer types, staging, treatment, and questions to ask the doctor.


Aaron Stone MD - twitter
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Genital Cosmetic Surgery - Designer Vagina

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Researchers at the UCL Elizabeth Garrett Anderson Institute of Women’s Health, University College Hospital in London, England looked at the first 5 websites that appeared on Google searches for female genital cosmetic surgery in the US and the UK. They then assessed the content of those sites for different criteria including what and how procedures were carried out, success rates, potential risks, terms used to describe the procedures.

They found that there was no consistency in terms used to describe the procedures or what the procedures actually involved. The terms used to describe procedures included "labioplasty" and "liposculpting" to "hoodectomy" "G spot enhancement" "vaginoplasty" "revirgination" "vaginal rejuvenation" and "hymenoplasty" which are actually all completely different procedures. Only 6 of the 10 listed possible complications of the surgery and none listed an age below which the procedure would be inappropriate. It is particularly disturbing that 343 such operations were performed on girls aged 14 or under in the UK between 2006 and 2012. The indications for surgery in this group of children are unknown, but labial anomalies requiring surgical interventions are extremely rare. A study last year revealed more than 2,000 women a year are receiving labial reduction or reshaping operations on the NHS.

The listed benefits of surgery were more youthful better appearing genitalia, reconstitution of virgin structures, improved personal hygiene, lowered risk of infection, enhanced sexual pleasure, restored confidence and improved self esteem. However, other than reconstitution of virgin structures none of these listed benefits have never been proven to be sufficiently dependent on any of these procedures to make this claim valid. No evidence-based data have been published to date that support these procedures.

Hardly any mentioned that women’s vulvas naturally differ from one another in size and appearance, the appearance constantly changes at part of the aging process and that a broad variety of appearances are normal.

According to the study, women typically seek genital cosmetic surgery because they’re not happy with the way they look in that area or because they think surgery might help them or their partners achieve greater sexual satisfaction. Their work appears in the "Obstetrics & Gynaecology" edition of the on-line journal BMJ Open. On RealSelf searches for labiaplasty increased 22% in 2012 compared to 2011.

Published complication rates range anywhere from 4% to 18%. Complications include pain with sex, bleeding, scarring, and improper healing. If the tightening is too extreme tissue can tear whenever the patient has sex and cause pain.


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How Long Does A Facelift Last?

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This a question most patients have going into facelift surgery and my usual answer was 5 to 10 years depending on genetics, age at surgery (it lasts longer in younger patients), exposure to extreme climates and active or passive smoking. Now a long study out of the UK shows that more than five years after facelift surgery, three-fourths of patients still look younger than they did before surgery. The researchers looked at photographs of 50 patients who had undergone facelift surgery an average of 5½ years previously. Surgical changes in the lines around the nose and mouth had the greatest longevity while the angle of chin to neck (the neck outline) changes deteriorated the most during this time frame. This is probably why neck revisions after facelift surgery are more common than revisions above the jaw line. The study does not tell us how long all of the changes last only that they last to some degree for more than 5 years.
One of my male facelift patients in his 60s did not require anything but a laser resurfacing a few years after facelift surgery and sculptra dermal filler injections 8 years after facelift surgery to maintain his results.

Facelift1
Facelift2
Male Facelift
Face and Neck Lift1
Face and Neck Lift2
Mini Facelift-Lifestyle Lift-Quick Lift

Aaron Stone MD - twitter
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Facial Feminization Surgery - Forehead and Jaw Contouring Reshaping

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Historically differentiation between male and female skulls was performed by anthropologists and medical examiners by analyzing nose, chin and forehead bone shapes in cadavers. Today it is common knowledge that faces contain secondary sex characteristics that develop during puberty and make male faces easily distinguishable from female faces. The female chin is more rounded or pointed than the square male chin and their less prominent noses have less angular tips . The male forehead has a prominence of bone, a horizontal ridge of bone, running across the forehead just above the eyebrows (bossing), followed by a concave area and then slopes upward and backward. The female forehead lacks bossing and the concave area above it and rises vertically rather than sloping upward and backward.
Additionally as is evident in these photos the angle of the lower jaw in front of and below the ears is more prominent in males
Facial feminization surgery (FFS) is a set of surgical procedures, first described in the late 1980s, that alter typically male facial features to make them closer in shape and size to typical female facial features. Facial feminization surgery includes various bone and/or soft tissue procedures such as foreheadplasty to change the shape of the forehead bone or move the frontal hairline, brow lift, rhinoplasty, cheek implantation, and lip augmentation as well as facial hair removal. FFS is medically necessary to treat gender dysphoria. It can be as or more important than genital forms of sex reassignment surgery to these patients thereby allowing them to integrate socially as women. Studies have shown that the mental health-related quality of life for trans women who have had FFS is significantly higher than for trans women who have not had FFS. Non-transsexual women who feel that their face is too masculine or simply want to improve their looks can also benefit from some of these procedures.

HAIRLINE CORRECTION BY SCALP ADVANCEMENT- HAIRGRAFTING - BROWLIFTING
In males the hairline is often higher than in females and usually has receded corners above the temples that give the hairline an “M” or "V" shape. Females have lower corners at the temples and are higher in the midline (an inverted U-shape). The hairline can be moved forwards and given a more rounded shape either with a procedure called a “scalp advance” where the scalp is lifted and repositioned or with hair transplantation. Hair transplants can also be used to thicken up hair that has been thinned by male pattern baldness. If too much hair has been lost, it will obviously not be possible to correct hairline problems.
scalp advancement
Before and After Scalp Advancement
Note the vertical orientation of this female forehead without forehead bossing. In genetic males feminization of the hairline requires advancement and reshaping to this pattern. Advancement alone is not sufficient and some patients only need advancement of the corners at the temples for feminization. The shape of the hairline is more important than the height! In performing the advancement inked needles are passed through the skin to mark the current and desired hairline level on the bone. An incision is made at the hairline and the scalp lifted up all the way to the back of the skull as needed. Relaxing incisions on the sides of the scalp an under it allow the scalp to come forward to the marked level on the bone, excess forehead skin is removed and the scalp is suture quilted to the skull to prevent later retraction of the scalp and over elevation of the eyebrows. This procedure is contraindicated in smokers due to the risk of loss of scalp tissue in such patients.

There is always a visible scar from a scalp advance but just how visible will be partly down to luck, partly down to the skill of the surgeon and partly down to your own tendency to scar. Many patients feel their scar is almost invisible except to people who know what they are looking for. The scalp advance technique severs two nerves that supply sensation to the scalp. The sensation often does not fully return and you may notice one or two numb or partially numb patches on your scalp. This is not generally a problem though and you only tend to notice the numbness if you are feeling for it. The hair growing near the incision may fall out after a scalp advance. This hair will start to grow again 3 to 4 months later

Since female eyebrows are typically higher than male eyebrows the advancement is designed to create a browlift at the same time when necessary. Doing so when it is not necessary will leave you with eyebrows in an unnaturally high position and an unusual "surprised" expression. In such cases the scalp advancement can be performed without a browlift.

FOREHEAD RECONTOURING 
Changing the shape of the skull in the forehead area (foreheadplasty) changes one feature from distinctly male (bossing and backward sloping) to distinctly female (vertical without bossing).
The forehead bone can be one of 3 types:
  1. The bone of the bossing is thick and the frontal sinus deep to it is small or absent and the bossing may appear greater than it actually is due to a deep concave or indented area just above it
  2. The bossing is present but the bone is thin and the frontal sinus may be large i.e. the bone is too thin to burr down
  3. The sinus is so large and protrudes so far forward that the bone cannot be burred or filed down without entering the sinus 
 The first is treated by burring with or without methylmethacrylate (shave and fill), the second with only methylmethacrylate placed to fill in the indented areas and the third by cutting the bone setting it backward, burring/reshaping as necessary and fixing it in position with wires or plates and screws. Absorbable plates and screws dissolve within 6 to 12 months. If the bone is cut, reshaped and fixed in place an overnight stay in an aftercare facility is prudent. Some patients have a tissue reaction to methylmethacrylate and secrete fluid around it for a week or two after surgery. This is removed with a syringe and needle until the body no longer produces it. Hydroxyapatite bone cement, commercially available as BoneSource, can be used instead of methylmethacrylate to smooth out any visible step between any bossing present after burring and the rest of the forehead to provider a smoother surface with a more vertical orientation for a more feminine appearance. All of these procedures can be performed via the same incision used for scalp advancement.
This is a case where the bone was cut out flattened and then placed back in position by Dr. Barry Eppley. This is a case of forehead reshaping without feminization because the backward upward slope of a male forehead was maintained.

RHINOPLASTY
Men have triangular shaped noses with wider bases near the upper lip and more downwardly displaced nasal tips than women. Female noses have a more concave contour along the sidewalls that flows smoothly downward from the inner end of the eyebrows. Standard rhinoplasty procedures are generally suffice to successfully feminize a nose. Rhinoplasty is effective in achieving female facial profiles in patients undergoing male-to-female sex reassignment.
These photos show the more triangular shaped male nose with a wider base compared to the concave sidewalls and narrower base of the female nose. Also note the higher eyebrows in the female and the more squared chin contour in the male.

asian rhinoplastyasian rhinoplasty
Feminization of the nose by making the sidewalls concave, raising the tip and narrowing the base in genetic females.


CHEEK IMPLANTS
Females often have more forward projection in their cheekbones as well as fuller cheeks overall. The fleshy part or “apple” of female cheeks contains more fat than the male and is therefore fuller and rounder – male cheeks are much more hollow here. The hormones taken by transsexual patients can increase the fat here but it may take a year of hormone therapy for this to occur so it is best to wait a year before doing cheek surgery. If this is insufficient free fat graft injections using fat liposuctioned from elsewhere on the body and/or shifting soft tissue at the time of facelift surgery can do the job. (See My Blog on Free Fat Grafting) Sometimes cheek implants are used to feminize cheeks. They come in different sizes and can be placed in different positions depending on the needs of the patient. Sometimes bone cement (hydroxyapatite cement) is used instead of silicone implants but various other materials such as goretex or porous polyethylene are also used.
cheek_implants
These medpor cheek implants were placed via an incision inside the mouth.

CHIN IMPLANTS OR RECONTOURING
Males tend to have taller chins than females with a deeper labiomental fold between the lower lip and chin. Female chins tend to be rounded and male chins tend to be square with a flat base and two corners. The chin can be reduced in height either by bone shaving or with a procedure called a “sliding genioplasty” where a section of bone is removed. The square corners can usually be shaved down. In other cases placement of a small round chin implant will suffice. Fat injection into the labiomental fold is a nice easy way to feminize the chin for those with deep labiomental folds. Sometimes liposuction is also used to remove some of the fat that some people have underneath the chin although that is more to improve looks than feminize the face. It is also a very good source of fat for the labiomental fold.

LIP AUGMENTATION
The distance between the opening of the mouth and the base of the nose tends to be longer in males than in females and in older individuals vs. younger individuals. When a female mouth is open and relaxed the upper incisors are often exposed by a few millimeters. Feminization has been performed by making an incision just under the base of the nose to remove a section of skin,"subnasal lift".  or removing a segment of skin just above the upper lip along its entire length,"vermilion advancement". I personally did not do either of these because of their potential for visible uncontrollable scarring. I prefer lip augmentation with fat injection or Alloderm and elevation during the process of a subperiosteal facelift. Neither of these approaches creates a visible skin scar between the nose and upper lip.
Lip augmentation using Alloderm to give a feminine pouty look..

Injectable fillers like Juvederm, Restylene etc are regularly used to augment lips but are not my preferred method because they do not last long.

LIPOSUCTION
Liposuction is more for improving looks than feminizing per se but can be used to masuclinize the face if performed to emphasize the jaw line or to harvest fat for feminizing fat injections.

JAW RESHAPING
Males’ jaws tend to be wider and taller than female jaws and often have a sharp corner at the back. The back corner can be rounded off in a procedure called “mandibular angle reduction”; bone can also be shaved off along the lower edge of the jaw to reduce width and height and the chewing muscles (masseter muscles) can also be reduced to make the jaw appear narrower. The angle reduction is performed via an incision inside the mouth using an x-ray template to prevent removing too much bone. Pressure dressing and a head up position are required to decrease swelling. An overnight stay in an aftercare facility is prudent to ensure that swelling is well controlled and that you can take food orally after surgery.

TRACHEAL SHAVING-ADAM'S APPLE REDUCTION
Males tend to have a much more prominent Adam's apple than females although small Adam's apples are more common in males than many people realise. The Adam's apple can be reduced with a procedure called a “tracheal shave” or “Chondrolaryngoplasty”. This is best done via an incision in the natural neck skin crease above the Adam's apple to give the least noticeable scar. It is not always possible to make a large Adam’s apple invisible with this procedure, rather the intent is to change it from the masculine 90 degree Adam's apple angle to the feminine 120 degree Adam's apple angle.

The voice is temporarily weakened by this procedure and the weakened state can last for as long as 6 months but permanent changes to the voice are possible. The cartilage that forms the Adam’s apple tends to harden with age and that may limit the amount that can be removed in an older patient. There is also a limit to how much can be removed without risking permanent damage to the voice. Basically, the Adam's apple is part of the front wall of the voice box and the vocal chords are attached to that wall - if the wall is thinned too much, it may no longer be strong enough to hold the vocal chords in full tension. This can leave the voice deeper and with a gravelly sound.

LASER HAIR REMOVAL OR ELECTROLYSIS OF THE BEARD


Beautification and rejuvenation procedures are often performed at the same time as facial feminization. For example, it is common for eye bags and sagging eyelids to be corrected with a procedure called “blepharoplasty” and many feminization patients undergo a face and neck lift (rhytidectomy). Along with scalp advancement/forehead recontouring the muscles creating frown lines between the eyebrows can be removed and the frown lines can be filled with grafts. It is often necessary for older patients to have a lower face-lift after jaw and chin surgery because the reduction in bone and the effects of swelling can leave sagging skin. Nasolabial folds between the nose and corners of the mouth can be diminished with filler injections. FFS is a very powerful set of procedures but there are limits; for example: a wide jaw can be feminized by surgical narrowing but it may not be physically possible to narrow a very wide jaw enough to make it fully female. There are also some masculine facial features that can't be surgically feminized at all like the relative size of the eyes to the skull (females tend to have proportionately larger eyes).


Facial proportions analysis in cosmetic surgery

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